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Interfacial and Bioanalytical Chemistry IBAC


Interfacial and Bioanalytical Chemistry

Interfacial and Bioanalytical Chemistry at the University of Utah provides a unique focus for graduate education in the Department of Chemistry. Ten research groups combine their state-of-the-art expertise in electroanalytical methods and scanning electrochemical microscopy, surface-plasmon resonance spectroscopy and microscopy, sum-frequency and second-harmonic generation, Raman microscopy, single-molecule fluorescence spectroscopy, and nanoscale self-assembled structures to address important research problems in both fundamental and applied areas of interfacial and bioanalytical chemistry. Courses selected from analytical, physical, and biological chemistry, applied mathematics, and bioengineering provide a foundation for graduate study and research. Biweekly seminars and journal club provide on-going contact with research groups in this area and encourage collaborative research. Informal social activities take advantage of life in Salt Lake City and recreational opportunities in nearby Wasatch and Uinta Mountains.

PhD Program

The IBAC PhD program equips students with the knowledge, skills, and experience necessary for a successful independent research career. Coursework, journal club, and joint research meetings expose students to research topics and techniques in interfacial and bioanalytical chemistry beyond their PhD research projects. IBAC students develop important communication skills through participation in seminars and writing research proposals. The social aspect of the program encourages the exchange of ideas between students and the development of collaborations between IBAC research groups.
  • IBAC students obtain a broad knowledge base needed for a successful independent research career by taking a variety of courses selected according to their research interests. During the first year of the PhD program, IBAC students typically take eight half-semester (7.5 weeks) courses in analytical chemistry and in areas related to their PhD research. Courses taught by participating IBAC faculty include:

    • Analytical and Chemical Measurements
    • Chemical Separations
    • Electrochemistry
    • Bioanalytical Chemistry
    • Information Processing
    • Optical Spectroscopy
    • Surface Chemistry
    • Chemical Instrumentation and Electronics

    In addition, many students take courses in other areas of chemistry, as well as in bioengineering, physics and math.

  • First-year IBAC students gain teaching experience as instructors in the Department's undergraduate quantitative analysis and analytical instrumentation laboratories. Students normally do not teach after their first year, unless they wish to emphasize instructional teaching in their studies.

     

  • Applications are submitted through the NSF ETAP system. 

    All IBAC students join research groups in the spring semester of the first year and begin their independent research projects in collaboration with a faculty advisor. Many students in recent years have successfully completed the PhD in four years (occasionally even less), but a typical PhD requires 4.5 years from the time a student enters the program.

    Research Groups

    Conboy Group

    The Conboy Group is actively developing novel analytical and bioanalytical techniques for the exploration of interfacial phenomena in biology and chemistry. We are currently pursuing research into the dynamics and structure of lipid membranes and the development of label-free methods for detecting protein and small-molecule adsorption to interfaces. Our laboratory uses a combination of nonlinear optical spectroscopies in conjunction with biological and electrochemical methods to achieve these objectives. Please peruse the selection of publications from our group listed below for more information about our research.

    Harris Group

    The research of the Harris Group is centered on novel approaches to chemical microscopy, which allows them to probe interfacial chemistry in sub-femtoliter volumes.  They have developed methods for depositing lipid bilayers in porous particles, for studying the binding of proteins to surface-immobilized ligands, and for investigating molecular adsorption and transport in individual porous particles.  Their chemical microscopy methods include vibrational (Raman) spectroscopy, for determining interfacial composition and structure, and single-molecule fluorescence imaging, for observing dynamics of individual molecules and for ultra-sensitive chemical analysis.

    Luo Group

    The Luo group is actively exploring the interdisciplinary frontiers of chemistry to address major challenges in the environment, energy, and health. They design, discover, and synthesize new functional materials and molecules. They also develop novel analytical methods, tools, and devices. The group values both in-depth fundamental understanding and real-world problem-solving. Current research focuses include temporal and spatial control of electroorganic synthesis, isotope labeling of pharmaceuticals, catalytic gas sensing, catalytic grain boundary materials, and rare earth element recycling.

    Minteer Group

    The Minteer Group focuses on improving the abiotic-biotic interface between biocatalysts and electrode surfaces for enhanced bioelectrocatalysis. These biocatalysts include microbial cells, organelles (mitochondria and thylakoid membranes), redox proteins, and oxidoreductase enzymes. We design electrode structures for enhanced flux at electrode surfaces for biosensor and biofuel cell applications. The group utilizes a variety of electroanalytical techniques (linear polarization, cyclic voltammetry, differential pulse voltammetry, differential pulse amperometry), as well as a variety of biological and spectroscopic techniques to accomplish these goals.

    Nagy Group

    Research in the Nagy Group is interested in better understanding how, why, and what, specific human milk oligosaccharides (HMOs) influence the relationship between the brain, gut, and immune system of an infant. To solve this puzzle, we are actively developing a bioanalytical workbench consisting of a new multidimensional separations platform to be used in conjunction with various solution and gas-phase chemical probes to enable better separation and characterization of this highly diverse class of unconjugated glycans. Additionally, we are exploring the use of accelerated reactions in microdroplets to permit rapid syntheses of biomedically-relevant glycan standards.

    Porter Group

    Porter groups aims at developing innovations central to the discovery and rapid screening of promising therapeutic compounds, nanomaterials, biomaterials, and biocatalysts. By creating high-throughput methods and miniaturizing analytical instrumentation, we are examining issues related, for example, to: (1) micro- and nanoelectronic and magnetic devices, (2) biosignatures for health and security, (3) chip-scale diagnostic platforms, and (4) chemical interaction databases.

    Shumaker-Parry Group

    The Shumaker-Parry group investigates novel nanomaterials for catalysis, photovoltaics, spectroscopy, and chemical and biological sensing through interdisciplinary research. Our approaches focus on nanoparticle synthesis and assembly, nanostructure fabrication, interfacial chemical analysis, and studies of physical properties of the nanomaterials. We use a wide range of materials characterization and spectroscopy tools depending on the scientific question under investigation. Our research emphasizes both fundamental investigations to elucidate material properties, including interfacial chemistry, as well as applications of the materials to meet challenging problems from catalysis to medically-relevant assays for diseases such as Multiple Sclerosis.

    White Group

    The White group is an interdisciplinary team that applies principles grounded in electrochemistry to advance understanding of a wide variety of physical systems. Systems currently investigated within the group span the physical, analytical and biological sciences. These include nano-pore/pipette based sensing, measuring and delivery of nanoscale particles; protein ion channel electrical measurements of nucleic acids; theoretical and electrochemical scanned probe investigations of solid-state batteries; experimental measurements and theoretical analysis of ionic transport in confined geometries; and fundamental studies of electrochemically generated nanobubbles.

    Zharov Group

    Current research in Zharov group is divided between three main areas: (1) functional membrane materials for energy and separations, (2) functional nanoparticles for biomedical applications and catalysis, and (3) nanoconfinement effects on chemical reactivity and on physical properties of hydrocarbons. Within these areas, the following projects are ongoing: (1) self-assembly of polymer brush nanoparticles into porous supercrystals, (2) ion-conducting membranes from self-assembly of polymer brush nanoparticles, (3) tailoring the nanoenvironment of diamond-supported noble metal nanoparticles for control of catalysis, (4) degradable silica nanoparticles, (5) investigation of nanoconfinement effect on reactivity of aryl cyanate esters, and (6) fluid-solid interactions inside nanopores.

  • In the second and third year, students present a departmental seminar and write a NSF or NIH-style research proposal to fulfill degree requirements. IBAC students attend the Department's Physical and Analytical Chemistry weekly seminar and the annual Analytical Chemistry Colloquium where they encounter cutting-edge research presented by leading scientists from all over the globe.

  • The IBAC research groups jointly meet twice a month on Friday afternoons for a journal club and for research presentations. The journal club and joint group meetings expose students to many areas of analytical chemistry beyond their own research projects. In each IBAC journal club meeting, two students present an important paper from the analytical chemistry literature (either a classic from the past or a new, cutting-edge article) that emphasizes fundamental principles of chemical analysis and instrumentation. Students also present their research to the IBAC groups at least once a year.

  • Social events such as the IBAC holiday party, summer barbeque, receptions for visitors, and occasional group outings provide opportunities for informal interactions between members of the IBAC research groups.

Schedule

Fridays at 11:30AM in TBBC 4630