Shelley D. Minteer – Department of Chemistry

Activities & Awards

2020 Bioelectrochemistry Prize of the International Society of Electrochemistry

2020 University of Utah Distinguished Research Award

2020 Charles N. Reilley Award of the Society of Electroanalytical Chemistry

2019 Fellow of the International Society of Electrochemistry

2019 Grahame Award of the Electrochemical Society

2018 Fellow of the American Association for the Advancement of Science

2018 American Chemical Society Analytical Division Electrochemistry Award

2015 Luigi Galvani Prize of the Bioelectrochemical Society

2013 Fellow of The Electrochemical Society

2010 Tajima Prize of the International Society of Electrochemistry

2008 American Chemical Society St. Louis Award

2008 Scientific American Top 50 Award

2008 Society of Electroanalytical Chemists Young Investigator Award

2006 U.S. Department of Defense Okaloosa Award

2006 Missouri Inventor of the Year Award

2005 Academy of Science of St. Louis Innovation Award

Research Interests

The Minteer Group focuses on improving the abiotic-biotic interface between biocatalysts and electrode surfaces for enhanced bioelectrocatalysis. These biocatalysts include microbial cells, organelles (mitochondria and thylakoid membranes), redox proteins, and oxidoreductase enzymes. We design electrode structures for enhanced flux at electrode surfaces for biosensor and biofuel cell applications. The group utilizes a variety of electroanalytical techniques (linear polarization, cyclic voltammetry, differential pulse voltammetry, differential pulse amperometry), as well as a variety of biological and spectroscopic techniques to accomplish these goals. The group also has an active program in electrocatalysis for synthetic organic electrochemistry.

Shelley Minteer is a director and member of CSOE.

Selected Publications

Chen, H.; Prater, M. B.; Cai, R.; Dong, F.; Chen, H.; Minteer, S. D., Bioelectrocatalytic Conversion from N2 to Chiral Amino Acids in a H2/alpha-Keto Acid Enzymatic Fuel Cell. J. Am. Chem. Soc. 2020,142 (8), 4028-4036.
Shrestha, A.; Hendriks, K. H.; Sigman, M. S.; Minteer, S. D.; Sanford, M. S., Realization of an Asymmetric Non-Aqueous Redox Flow Battery through Molecular Design to Minimize Active Species Crossover and Decomposition. Chemistry – A European Journal 2020,26 (24), 5369-5373.
Yuan, M.; Abdellaoui, S.; Chen, H.; Kummer, M. J.; Malapit, C. A.; You, C.; Minteer, S. D., Selective Electroenzymatic Oxyfunctionalization by Alkane Monooxygenase in a Biofuel Cell. Angew. Chem. Int. Ed. 2020,59 (23), 8969-8973.
Dong, F.; Chen, H.; Malapit, C. A.; Prater, M. B.; Li, M.; Yuan, M.; Lim, K.; Minteer, S. D., Biphasic Bioelectrocatalytic Synthesis of Chiral beta-Hydroxy Nitriles. J. Am. Chem. Soc. 2020,142 (18), 8374-8382.
Lim, K.; Macazo, F. C.; Scholes, C.; Chen, H.; Sumampong, K.; Minteer, S. D., Elucidating the mechanism behind the bionanomanufacturing of gold nanoparticles using Bacillus subtilis. ACS Appl. Bio Mater. 2020.
Lee, Y. S.; Yuan, M.; Cai, R.; Lim, K.; Minteer, S. D., Nitrogenase Bioelectrocatalysis: ATP-Independent Ammonia Production Using a Redox Polymer/MoFe Protein System. ACS Catal. 2020, 10, 6854-6861
B.K. Peters, K.X. Rodriguez, S.H. Reisberg, S.B. Beil, D.P. Hickey, Y. Kawamata, M. Collins, J. Starr, L. Chen, S. Udyavara, K. Klunder, T. Gorey, S.L. Anderson, M. Neurock, S.D. Minteer, and P.S. Baran, “Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry,” Science, 2019, 363, 838-845.
G. Pankratova, D. Pankratov, R.D. Milton, S.D. Minteer, and L. Gorton, “Following Nature: Bioinspired Mediation Strategy for Gram-positive Bacterial Cells,” Advanced Energy Materials, 2019, 1900215.
H. Chen, R. Cai, J. Patel, F. Dong, H. Chen, and S.D. Minteer, “Upgraded Bioelectrocatalytic N2 Fixation to Chiral Amine Intermediates,” Journal of the American Chemical Society, 2019, 141, 4963-4971.
Y. Kawamata, J.C. Vantourout, D.P. Hickey, P. Bai, L. Chen, Q. Hou, W. Qiao, K. Barman, M. Edwards, A. Garrido-Castro, J. deGruyter, H. Nakamura, K. Knouse, C. Qin, K. Clay, D. Bao, C. Li, J. Starr, C. Garcia-Irizarry, N. Sach, H. White, M. Neurock, S.D. Minteer, and P. Baran, “Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications,” Journal of the American Chemical Society, 2019, 141, 6392-6402.
M. Yuan, M. Kummer, R. Milton, T. Quah, and S.D. Minteer, “Efficient NADH Regeneration by a Redox Polymer-Immobilized Enzymatic System,” ACS Catalysis, 9, 5486-5495.
B. Bulutoglu, F. Macao, J. Bale, N. King, D. Baker, S.D. Minteer, and S. Banta, “Multimerization of an Alcohol Dehydrogenase by Fusion to a Designed Self-Assembling Protein Results in Enhanced Bioelectrocatalytic Operational Stability,” ACS Applied Materials & Interfaces, 2019, 11, 20022-20028.
L. Lancaster, D.H. Hickey, M.S. Sigman, S.D. Minteer, and I. Wheeldon, “Bioinspired design of a hybrid bifunctional enzymatic/organic electrocatalyst for site selective alcohol oxidation,” ChemComm, 2018, 54, 491-494.
K. Hendriks, S. Robinson, M. Braten, C. Sevov, B. Helms, M. Sigman, S. Minteer, and M. Sanford, “High-Performance Oligomeric Catholytes for Effective Macromolecular Separation in Nonaqueous Redox Flow Batteries,” ACS Central Science, 2018, 4(2), 189-196.
S. Abdellaoui, F. Macazo, R. Cai, A. de Lacey, M. Pita, and S.D. Minteer, “Enzymatic Electrosynthesis of Alkanes via Bioelectrocatalytic Decarbonylation of Fatty Aldehydes,” Angewandte Chemie, 2018, 57, 2404-2408.
R. Cai, R. Milton, S. Abdellaoui, T. Park, J. Patel, B. Alkotaini, and S.D. Minteer, “Electroenzymatic C-C bond formation from CO2,” Journal of the American Chemical Society, 2018, 140, 5041-5044.
M. Yuan, S. Sahin, R. Cai, S. Abdellaoui, D.P. Hickey, S.D. Minteer, and R.D. Milton, “Creating a low-potential redox polymer for efficient electroenzymatic CO2 reduction,” Angewandte Chemie, 2018, 130, 6692-6696.
S.L. Foster, S.I. Perez Bakovic, R. Duda, S. Maheshwari, R.D. Minteer, S.D. Minteer, M.J. Janik, J.N. Renner, and L.F. Greenlee, “Catalysts for Nitrogen Reduction to Ammonia,” Nature Catalysis, 2018, 1, 490-500.
D.P. Hickey, K. Lim, R. Cai, A. Patterson, M. Yuan, S. Sahin, S. Abdellaoui, and S.D. Minteer, “Pyrene Hydrogel for Promoting Direct Bioelectrochemistry: ATP-Independent Electroenzymatic Reduction of N2,” Chemical Science, 2018, 9, 5172-5177.
J. Kitt, D. Bryce, S.D. Minteer, and J. Harris, “Confocal Raman Microscopy for In-situ Measurement of Phospholipid-Water Partitioning into Model Phospholipid Bilayers within Individual Chromatographic Particles,” Analytical Chemistry, 2018, in press.
R.D. Milton, R. Cai, S. Sahin, S. Abdellaoui, B. Alkotaini, D. Leech, and S.D. Minteer, “The In Vivo Potential-Regulated Protective Protein of Nitrogenase in Azotobacter vinelandii Supports Aerobic Bioelectrochemical Dinitro-gen Reduction In Vitro,” Journal of the American Chemical Society, 2017, 139, 9044-9052.
R.D. Milton and S.D. Minteer, “Direct Enzymatic Bioelectrocatalysis: Differentiating Between Myth and Reality,” Journal of the Royal Society Interface, 2017, 14, 20170253.
L. Xia, K. Nguyen, Y. Holade, H. Han, K. Dooley, P. Atanassov, S. Banta, and S.D. Minteer, “Improving the Performance of Methanol Biofuel Cells Utilizing an Enzyme Cascade Bioanode with DNA Bridged Substrate Channeling,” ACS Energy Letters, 2017, 2, 1435-1438.
S. Abdellaoui, M. Snow, I. Matanovic, A. Stephens, P. Atanassov, and S.D. Minteer, “Hybrid Molecular/Enzymatic Catalytic Cascade for Complete Electro-oxidation of Glycerol Using a Promiscuous NAD-dependent Formate Dehydrogenase from Candida boidinii,” ChemComm, 2017, 53, 5368 - 5371.
Y. Liu, D.P. Hickey, J.Y. Guo, E. Earl, S. Abdellaoui, R. Milton, M.S. Sigman, S.D. Minteer, and S. Calabrese Barton, “Substrate Channeling in an Artificial Metabolon: A Molecular Dynamics Blueprint for an Experimental Peptide Bridge,” ACS Catalysis, 2017, 7, 2486-93.
M. Grattieri, N.D. Shivel, I. Sifat, M. Bestetti, and S.D. Minteer, “Sustainable Hypersaline Microbial Fuel Cells: Inexpensive Recyclable Polymer Supports for Carbon Nanotube Conductive Paint Anodes,” ChemSusChem, 2017, 10, 2053-2058.
K. Knoche, K. Hasan, E. Aoyama, and S.D. Minteer, “Role of Nitrogenase and Ferredoxin in the Mechanism of Bioelectrocatalytic Nitrogen Fixation by the Cyanobacteria Anabaena variabilis SA-1 Mutant Immobilized on Indium Tin Oxide (ITO) Electrodes,” Electrochimica Acta, 2017, 232, 396-403.
J. Kitt, D. Bryce, S.D. Minteer, and J.M. Harris, “Raman Spectroscopy Reveals Selective Interactions of Cytochrome c with Cardiolipin that Correlate with Membrane Permeability,” Journal of the American Chemical Society, 139(10), 3851-3860.
K. Hasan, R. Milton, M. Grattieri, T. Wang, M. Stephanz, and S.D. Minteer, “Photobioelectrocatalysis of Intact Chloroplasts for Solar Energy Conversion,” ACS Catalysis, 2017, 7, 2257-2265.
C. Serov, D.P. Hickey, M. Cook, S. Robinson, S. Barnett, S.D. Minteer, M.S. Sigman, and M. Sanford, “A Physical Organic Approach to Persistent, Cyclable, Low-Potential Electrolytes for Flow Battery Applications,” Journal of the American Chemical Society, 2017, 139, 2924-2927.
R.D. Milton, R. Cai, S. Abdellaoui, D. Leech, A.L. De Lacey, M. Pita, and S.D. Minteer, “Bioelectrochemical Haber-Bosch Process: An Ammonia-Producing H2/N2 Fuel Cell,” Angewandte Chemie, 2017, 56(10), 2680-2683.
R.D. Milton, S. Abdellaoui, D. Dean, L. Seefeldt, D. Leech, and S.D. Minteer, “Nitrogenase bioelectrocatalysis: heterogeneous ammonia and hydrogen production by MoFe protein,” Energy and Environmental Science, 2016, 9, 2550-2554.
L. Pelster and S.D. Minteer, “Mitochondrial Inner Membrane Biomimic for the Investigation of Electron Transport Chain Supercomplex Bioelectrocatalysis,” ACS Catalysis, 2016, 6, 4995-4999.
K. Knoche, D.P. Hickey, R.D. Milton, C. Curchoe, and S.D. Minteer, “Hybrid Glucose/O2 Biobattery and Supercapacitor Utilizing a Pseudocapacitive Dimethylferrocene Redox Polymer at the Bioanode,” ACS Energy Letters, 2016, 1, 380-385.
B. Bulutoglu, K.E. Garcia, F. Wu, S.D. Minteer, and S. Banta, “Direct evidence for metabolon formation and substrate channeling in recombinant TCA cycle enzymes,” ACS Chemical Biology, 2016, 11, 2847-2853.
T. Wang and S.D. Minteer, “Effect of Riboflavin Metabolites on Mitochondrial Electrochemistry,” Journal of the Electrochemical Society, 2016, 163(13), H1047-1052.
C. Tapia, R.D. Milton, G. Pankratova, S.D. Minteer, H. Akerlund, D. Leech, A. De Lacey, M. Pita, and L. Gorton, “Wiring of Photosystem I and Hydrogenase on an Electrode for Photoelectrochemical H2 Production using Redox Polymers for Relatively Positive Onset Potential,” ChemElectroChem, 2017, 4, 90-95.
Y. Holade, D.P. Hickey, and S.D. Minteer, “Halide-Regulated Growth of Electrocatalytic Metal Nanoparticles Directly on Carbon Paper Electrodes,” Journal of Materials Chemistry A, 2016, 4, 17154-17162.
D. P. Hickey, K.L. Knoche, K. Albertson, C. Castro, R.D. Milton, and S.D. Minteer, “Improving O2 Reduction at an Enzymatic Biocathode: Mimicking the Lungs,” ChemComm, 2016, 52, 13299-13302.
T. Wang, R.D. Milton, S. Adellaoui, D.P. Hickey, and S.D. Minteer, “Laccase Inhibition by As3+/As5+: Determination of Inhibition Mechanism and Preliminary Application to a Self-Powered Biosensor,” Analytical Chemistry, 2016, 88, 3243-3248.
R.D. Milton, T. Wang, K. Knoche, and S.D. Minteer, “Tailoring Biointerfaces for Electrocatalysis,” Langmuir, 2016, 32, 2291-2301.
I. Wheeldon, S.D. Minteer, S. Banta, S. Calabrese Barton, P. Atanassov, and M. Sigman, “Substrate channeling as an approach to cascade reactions,” Nature Chemistry, 2016, 8, 299-309.